An Analysis by Synthesis Approach for Automatic Vertebral Shape Identification in Clinical QCT

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Authors Stefan Reinhold. Timo Damm, Reinhard Barkmann, Claus-C. Gl├╝er, Reinhard Koch, Reimer Andresen, Lukas Huber
Journal/Conference Name Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Paper Category
Paper Abstract Quantitative computed tomography (QCT) is a widely used tool for osteoporosis diagnosis and monitoring. The assessment of cortical markers like cortical bone mineral density (BMD) and thickness is a demanding task, mainly because of the limited spatial resolution of QCT. We propose a direct model based method to automatically identify the surface through the center of the cortex of human vertebra. We develop a statistical bone model and analyze its probability distribution after the imaging process. Using an as-rigid-as-possible deformation we find the cortical surface that maximizes the likelihood of our model given the input volume. Using the European Spine Phantom (ESP) and a high resolution \mu CT scan of a cadaveric vertebra, we show that the proposed method is able to accurately identify the real center of cortex ex-vivo. To demonstrate the in-vivo applicability of our method we use manually obtained surfaces for comparison.
Date of publication 2018
Code Programming Language C++
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